Trabalhos do Hemocentro que serão apresentados no congresso ASH 2021

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Neutralization of Inflammasome-Processed Cytokines Reduces Inflammatory Mechanisms and Leukocyte Recruitment in the Vasculature of TNF-α-Stimulated Sickle Cell Disease Mice

Tipo de apresentação: Oral
Lidiane S. Torres, PhD^1*, Erica M.F. Gotardo, Ph.D.^2*, Flávia Costa Leonardo, Ph.D^2*, Pamela L. Brito, M.Sc.^2*, Irmgard Förster, Ph.D.^3*, Jiri Kovarik, Ph.D.^4*, Fernando Ferreira Costa, MD, PhD² and Nicola Conran, Ph.D.²

Final Results of the Fibromet Trial: An Open Label Phase II Study to Evaluate Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients

Tipo de apresentação: Poster
Paula De Melo Campos, MD, PhD¹, Katia B Pagnano, MD, PhD¹, Rubia Isler Mancuso, BSc, MSc^1*, Fernanda Isabel Della Via, BSc, MSc^1*, Ângela Condotta Tinoco, BSc^2*, Guilherme Rossi Assis-Mendonça, MD, PhD^2*, Leandro Luiz Lopes Freitas, MD, PhD^2*, Fabiola Traina, MD, PhD³ and Sara T Olalla Saad, MD, PhD¹

A Novel WNT5A-Mimicking Peptide Affects Leukemia Cell Survival in the Bone Marrow Microenvironment

Program: Oral and Poster Abstracts
Fernanda Marconi Roversi^1*, Maura Lima Pereira Bueno, undergraduate^1*, Rafael Gonçalves Barbosa Gomes, PhD/posdoc fellow/training^1*, Guilherme Rossi Assis-Mendonça, MD, PhD^2*, Paulo Latuf Filho, PhD^3*, Adriana Silva Santos Duarte, PhD^1* and Sara T Olalla Saad, MD, PhD⁴

COVID-19 in Patients with Chronic Myeloid Leukemia: Poor Outcomes for Patients with Comorbidities, Older Age, Advanced Phase Disease, and Those from Low-Income Countries: An Update of the Candid Study

Tipo de apresentação: Oral

Katia B Pagnano, MD, PhD1, Chung Hoow Kok, BSc, PhD2*, Michael J. Mauro, MD3, Jorge E. Cortes, MD4, Nicola Evans5*, Qian Jiang, MD6, Dragana Milojkovic7*, Beatriz Moiraghi, MD8*, Franck E. Nicolini, MD, PhD9, Matilda Ongondi, MD10*, Daniela Zackova, MD11,12*, Delphine Rea, MD, PhD13 and Timothy P. Hughes, MD, MBBS, FRACP, FRCPA14

Final Results of the Fibromet Trial: An Open Label Phase II Study to Evaluate Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients

Program: Oral and Poster Abstracts
Paula De Melo Campos, MD, PhD1, Katia B Pagnano, MD, PhD1, Rubia Isler Mancuso, BSc, MSc1*, Fernanda Isabel Della Via, BSc, MSc1*, Ângela Condotta Tinoco, BSc2*, Guilherme Rossi Assis-Mendonça, MD, PhD2*, Leandro Luiz Lopes Freitas, MD, PhD2*, Fabiola Traina, MD, PhD3 and Sara T Olalla Saad, MD, PhD1

The Importance of Bone Marrow Lymphocyte Subtypes As Predicting Factors for Molecular Recurrence in Patients with Chronic Myeloid Leukemia after Discontinuation of Imatinib

Program: Oral and Poster Abstracts
Arthur Gomes Oliveira Braga1,2*, Katia B Pagnano, MD, PhD1, Marina Dal’Bó Pelegrini Campioni, BSc3*, Ana Beatriz P Lopez1*, Konradin Metze, MD, PhD4*, Gislaine B O Duarte, MD1* and Irene Lorand-Metze, MD, PhD5*

Clinical Significance of Mitochondrial DNA Content in Acute Promyelocytic Leukemia

Program: Oral and Poster Abstracts
Antonio R. Lucena-Araujo, PhD1*, Diego A Pereira-Martins, MSc2,3*, Juan L Coelho-Silva, PhD4,5*, Isabel Weinhäuser, MSc2*, Pedro Luis Franca-Neto, PhD6*, Douglas RA Silveira, MD7,8*, Marinus M Lima, MD9*, Jan Jacob Schuringa, PhD10,11*, Luisa C Koury, MD4*, Raul Antônio Morais Melo, MD, PhD12*, Rosane Bittencourt, MD13*, Katia B Pagnano, MD, PhD14*, Elenaide C. Nunes, MD15*, Evandro Maranhão Fagundes, MD16, Fabio R. Kerbauy, MD17*, Lorena Figueredo-Pontes, MD, PhD18,19* and Eduardo M Rego, MD, PhD19,20

COVID-19 Diagnosis and Its Impact on Thrombotic Risk in a Cohort of Patients Simultaneously Hospitalized Due to Acute Respiratory Distress Syndrome

Tipo de apresentação: Oral

Andréa Coy-Canguçu^1*, Gisele Aparecida Locachevic^2*, João Carlos Silva Mariolano^2*, Kaio Henrique De Oliveira Soares^2*, José Diogo Oliveira^2*, Camila de Oliveira Vaz^2*, Gislaine Vieira Damiani^2*, Bruna Mazetto^2*, Joyce Maria Annichino- Bizzacchi, MD, PhD^3*, Erich V De Paula, MD, PhD³ and Fernanda Andrade Orsi, MD, PhD³

Circulating Levels of Ang/Tie2 and VEGF-a Pathway Mediators Are Associated with Clinical Severity, Endothelial Barrier Disruption and Coagulation Activation in COVID-19

Program: Oral and Poster Abstracts

Prêmio Abstract Achievement Award

Carla Roberta Peachazepi de Moraes^1*, Ivanio Teixeira de Borba Junior^1*, Franciele de Lima^1*, Mayck Silva Barbosa^1*, Stephany Cares Huber, PhD^1*, Andre C. Palma^1*, Thyago A. Nunes^1*, Raisa G. Ulaf^1*, Luciana C. Ribeiro^1*, Ana Flavia Bernandes^1*, Bruna Bombassaro^1*, Sergio S. Dertkigil^1*, Maria Luiza Moretti^1*, Joyce Annichino Bizzacchi, MD, PhD^1*, Eli Mansour, MD, PhD^1*, Lício Augusto Velloso, MD, PhD^1*, Fábio Trindade Maranhão Costa, PhD^2*, Fernanda Andrade Orsi, MD, PhD¹ and Erich V De Paula, MD, PhD¹

LIN28B and ZBTB8B Genes Are Highly Expressed in Vitro in a CD34⁺ Cells Subpopulation of β-Thalassemia Major Patients and May be Involved in Increased HbF Production

Program: Oral and Poster Abstracts
Flávia Peixoto Albuquerque, MSc, BSc^1*, Ingrid Grazielle Sousa, BSc, MSc^1*, Bruno Batista Souza, PhD^2*, Jersey Heitor da S Maués, PhD^1*, Carolina Lanaro, BSc, PhD^1*, Dulcinéia Martins de Albuquerque, BSc, PhD^1* and Fernando Ferreira Costa, MD, PhD¹

Monocytes from Patients with Polycythemia Vera Express Molecules Related to Stress Erythropoiesis and Have Increased Erythrocyte Phagocytosis

Program: Oral and Poster Abstracts
Marina Dorigatti Borges, BSc, MSc^1*, Renata Sesti-Costa, PhD^1*, Dulcinéia Martins de Albuquerque, BSc, PhD^1*, Carolina Lanaro, BSc, PhD^1*, Kleber Yotsumoto Fertrin, MD, PhD² and Fernando Ferreira Costa, MD, PhD¹

Sickle Cell Disease Mortality in Brazil: Real-World Evidence

Program: Oral and Poster Abstracts
Rodolfo D Cançado¹, Fernando Ferreira Costa, MD, PhD², Clarisse Lobo, MD, PhD³, Celina Borges Migliavaca^4*, Maicon Falavigna^4*, Homero C. R. Souza Filho^5*, Carolina Tosin Bueno, PhD^6* and Ana Cristina Silva Pinto, MD, PhD^7*

Crizanlizumab Therapy Is Associated with Lower Levels of Circulating Extracellular Vesicles in Sickle Cell Disease Patients

Program: Oral and Poster Abstracts
Cristiane Maria de Souza, BSc., MSc^1*, Carolina Lanaro, BSc, PhD^1*, Irene Pereira dos Santos^1*, Oladele Olatunya, MD^1*, Sara T Olalla Saad, MD, PhD¹, Bruno Deltreggia Benites, MD, PhD¹, Paula De Melo Campos, MD, PhD¹, Kleber Yotsumoto Fertrin, MD, PhD² and Fernando Ferreira Costa, MD, PhD¹[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][/vc_column][/vc_row]